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Colonic polyps in patients with acromegaly

I Klein, G Parveen, J S Gavaler

Annals of Internal Medicine

|July 1, 1982

Summary

Acromegaly patients show a higher incidence of colonic polyps, particularly adenomatous types, and a correlation with skin tags and age. This suggests increased risk for colorectal issues in acromegaly.

Area of Science:

Endocrinology
Gastroenterology
Oncology

Background:

Acromegaly is a hormonal disorder caused by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1).
The association between acromegaly and gastrointestinal pathology, specifically colorectal polyps and cancer, requires further investigation.

Purpose of the Study:

To prospectively evaluate the frequency of colonic polyps and colon cancer in patients with acromegaly.
To identify potential risk factors and correlations associated with colorectal neoplasia in this patient cohort.

Main Methods:

Seventeen patients with acromegaly underwent barium enemas and colonoscopy.
Colonic polyps were removed, examined histopathologically, and correlated with clinical factors such as skin tags and patient age.

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A retrospective review of 44 acromegaly patients' records was conducted for colon carcinoma diagnoses.

Main Results:

Colonic polyps were detected in nine of seventeen patients (53%).
Eight polyps were examined, with five being adenomatous, and four of these patients had multiple polyps.
Polyp presence significantly correlated with skin tags (p=0.041) and patient age (p<0.01).
No new colon cancer cases were found in the prospective study, but four prior diagnoses were identified in the retrospective review.

Conclusions:

Acromegaly patients exhibit an increased prevalence of colonic polyps, including adenomatous types.
The findings suggest that acromegaly may be associated with an elevated risk for colorectal polyps and potentially colon cancer.
Skin tags and advanced age are identified as potential correlating factors for polyp development in acromegaly.