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Updated: May 5, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Haloperidol-induced chronic cholestatic liver disease
This case study presents a 15-year-old patient who developed chronic cholestatic liver disease, likely due to haloperidol. The study highlights the bile duct injury and clinical features mimicking other liver conditions.
Area of Science:
- Hepatology
- Pharmacology
- Pathology
Background:
- Presents a rare case of chronic cholestatic liver disease in a 15-year-old.
- Investigates the potential link between haloperidol therapy and liver injury.
Observation:
- Detailed biochemical abnormalities and histologic features of bile duct epithelium injury.
- Clinicopathologic features evolved, mimicking obstructive jaundice and later primary biliary cirrhosis.
Findings:
- Four serial liver biopsies revealed progressive bile duct injury correlating with clinical presentation.
- Features were compared with previously reported acute haloperidol-induced liver disease.
Implications:
- Suggests haloperidol can induce chronic cholestatic liver reactions, possibly via hypersensitivity.
- Highlights the importance of considering drug-induced liver injury in cholestatic conditions.
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