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[Remodelling in rickets and osteomalacia (author's transl)]
Nihon Seikeigeka Gakkai Zasshi
|April 1, 1982
Summary
Bone remodelling in rickets and osteomalacia shows reduced cellular activity but variable tissue-level responses. This study investigates the complex bone changes in these metabolic bone diseases.
Area of Science:
- Bone biology
- Metabolic bone disease
- Histomorphometry
Context:
- Rickets and osteomalacia are characterized by impaired bone mineralization.
- Understanding bone remodelling dynamics is crucial for managing these conditions.
Purpose:
- To investigate bone remodelling processes in patients with rickets and osteomalacia.
- To analyze histomorphometric parameters and serum markers associated with bone disease.
Summary:
- Histomorphometry revealed increased osteons with osteoid seams and decreased resorption cavities.
- Tetracycline uptake was significantly depressed (9.7%), hindering bone formation rate measurement.
- Serum alkaline phosphatase dynamics suggest regulation by osteoblast activity, number, and elution.
- Accretion rate and urinary hydroxyproline excretion showed variable levels.
- Bone remodelling is consistently low at the cellular level but can vary at tissue/organ levels.
Impact:
- Provides insights into the cellular and tissue-level alterations in bone remodelling in rickets and osteomalacia.
- Highlights the challenges in measuring bone formation rates using tetracycline labelling in these diseases.
- Suggests a multifactorial regulation of serum alkaline phosphatase in metabolic bone disorders.