Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central gating of developmental plasticity in kitten visual cortex

W Singer, F Tretter, U Yinon

    The Journal of Physiology
    |March 1, 1982
    PubMed
    Summary

    Surgically rotating a kitten's eye causes severe visual impairment and abnormal visual cortex development. This suggests a central mechanism prevents inappropriate visual signals from impacting neural pathway consolidation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Accuracy of chat-based artificial intelligence for patient education on orthostatic hypotension.

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2025
    Same author

    [Differentiating cochlear synaptopathies into different hearing disorders].

    HNO·2019
    Same author

    Neurofeedback Training of Gamma Oscillations in Monkey Primary Visual Cortex.

    Cerebral cortex (New York, N.Y. : 1991)·2019
    Same author

    [Pain and opioid dependency as multilevel network phenomenon : Theoretical and metatheoretical aspects].

    Schmerz (Berlin, Germany)·2016
    Same author

    Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome.

    Neurogastroenterology and motility·2014
    Same author

    Midodrine efficacy in orthostatic hypotension.

    Journal of general internal medicine·2014

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Ophthalmology

    Background:

    • The visual system's development relies on appropriate visual input.
    • Abnormal visual input during critical periods can lead to lasting visual deficits.
    • Understanding these mechanisms is crucial for treating visual impairments.

    Purpose of the Study:

    • To investigate the effects of surgically rotated vision on visual cortex development and behavior in kittens.
    • To determine if abnormal visual input disrupts normal visual pathway formation.
    • To explore the underlying neural mechanisms responsible for visual processing deficits.

    Main Methods:

    • Kittens underwent surgical eye rotation and were reared in a lighted environment.
    • Behavioral assessments evaluated visual-motor coordination and visually guided behavior.
    • Single-unit recordings and evoked potentials were used to analyze striate cortex function.
    • Control experiments ruled out retinal or optic nerve damage as causes.

    Main Results:

    • Kittens exhibited progressive visual disturbances, ceasing to respond to visual stimuli.
    • Striate cortex recordings revealed reduced light-responsive cells and abnormal receptive fields.
    • Contrast sensitivity was significantly reduced across all spatial frequencies.
    • Ocular dominance shifts were less pronounced and diminished over time compared to controls.

    Conclusions:

    • Surgically induced abnormal visual input severely impairs visual behavior and cortical function.
    • These findings suggest a central inhibitory mechanism prevents aberrant visual signals from consolidating neural pathways.
    • This study highlights the critical role of normal visual experience in establishing functional visual circuits.

    Related Experiment Videos