Related Experiment Video
Updated: Sep 2, 2026

Isolation of Small Noncoding RNAs from Human Serum
Published on: June 19, 2014
Serum ribonuclease of normal persons and patients with renal impairment
Abstract:
Serum ribonuclease of normal persons and of patients with renal impairment was determined with polycytidylic acid as substrate. There was a pronounced rise in the serum ribonuclease of patients with renal impairment. Average serum ribonuclease values of 25 normal persons and 25 patients with renal impairment, respectively were 110 and 2329 units per ml of serum. Serum ribonuclease, because of its unique specificity, stability and abnormal elevation in the sera of patients with renal failure, might serve as an additional indicator in the assessment of renal function.
Related Concept Videos
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Nephrotic Syndrome II : Assessment and Medical Management
Serum Studies: Renal Function Tests

