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Updated: Jul 14, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Published on: May 17, 2014
Evolution of early mechanisms of translation of genetic information into polypeptides
Abstract:
In devising models of the origin of life it is necessary to tackle the problems that the processes of genetic information transfer that are central to life depend on molecules that are themselves the products of such processes--enzymes. A proposed model must eventually yield a detailed chain of processes that can be checked experimentally. We have developed a model in which interactions between the helices of hairpin-loop 'adaptor' RNA molecules (amino acid carrying), lined up side-by-side by sequence complementarity to another 'messenger' RNA, promotes polypeptide synthesis.
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins: From Genes to Degradation
Transcription is the synthesis of RNA molecules by RNA...

