Granulomatous reaction to Choyce style intraocular lens

Despite the large number of intraocular lens implants performed since Ridley first devised the procedure, there have been few reports of postmortem examination in clinically successful cases. We report a patient who tolerated his Choyce Mark VIII style implant well, despite a three-month episode of mild nongranulomatous uveitis occurring two months postoperatively, until his death 17 months later. This is the sixth postmortem study of an anterior chamber IOL and the only one in which there was a conspicuous granulomatous reaction on the anterior iris surface, with large foreign body giant cells. Despite the presence of a foreign body, the previous eyes that have clinically tolerated implants well and have come to postmortem examination have shown remarkably little inflammation; none have shown this degree of granulomatous reaction previously.