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Natriuretic factor, a lasting enigma

A Licht, L G Fine, J J Bourgoignie

Contributions to Nephrology

|January 1, 1978

Summary

This summary is machine-generated.

Uremic natriuretic factor, a substance found in the urine of patients with chronic kidney disease, inhibits sodium transport in the nephron. This discovery may lead to a quantitative assay for this potential modulator of sodium excretion.

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Area of Science:

Nephrology
Renal Physiology
Urology

Background:

Chronic uremia is associated with altered sodium balance.
The mammalian nephron plays a crucial role in regulating sodium excretion.
A natriuretic factor has been hypothesized to modulate renal sodium handling.

Purpose of the Study:

To investigate the effects of a urinary natriuretic factor from uremic patients on sodium transport.
To explore the potential of this factor as a modulator of sodium excretion in the mammalian nephron.
To characterize the physicochemical properties of the natriuretic factor.

Main Methods:

Gel filtration chromatography of urine from chronic uremic patients.
Perfusion of isolated rabbit cortical collecting tubules.

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Measurement of electrical potential difference and sodium flux.

Short-circuit current measurements in isolated toad bladder.

High-performance liquid chromatography with cation exchange.

Main Results:

The natriuretic factor decreased potential difference, net sodium flux, and lumen to peritubular sodium flux in the rabbit cortical collecting tubule.
A dose-dependent inhibition of short-circuit current was observed in the toad bladder.
The factor's acidic nature was confirmed using cation exchange chromatography.

Conclusions:

The findings suggest that uremic natriuretic factor modulates sodium excretion in the mammalian nephron.
The observed effects support the role of this factor in regulating renal sodium handling.
Further development of a quantitative assay for natriuretic factor is feasible.