Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure of human luteinizing hormone alpha subunit

H T Keutmann, B Dawson, W H Bishop

    Endocrine Research Communications
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Visual access to an outdoor range early in life, but not environmental complexity, increases meat chicken ranging behavior.

    Poultry science·2023
    Same author

    Leukocyte-dependent effects of platelet-rich plasma on cartilage loss and thermal hyperalgesia in a mouse model of post-traumatic osteoarthritis.

    Osteoarthritis and cartilage·2020
    Same author

    Flock use of the range is associated with the use of different components of a multi-tier aviary system in commercial free-range laying hens.

    British poultry science·2019
    Same author

    The need for an alternative method to determine intravascular volumes.

    European journal of sport science·2018
    Same author

    The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery: clinical trial.

    The Journal of laryngology and otology·2017
    Same author

    Formal evaluation of PYNK: Breast Cancer Program for Young Women-the patient perspective.

    Current oncology (Toronto, Ont.)·2016
    Same journal

    Uterine hydrogen peroxide concentrations and peroxidase activities in the estrous cycle and perimaturation period of mice.

    Endocrine research communications·1982
    Same journal

    Renin-angiotensin-aldosterone system in hyper- and hypothyroid rats during sodium depletion.

    Endocrine research communications·1982
    Same journal

    Effect of neurotensin on specific activity of plasma cholesterol following intravenous administration of cholesterol-4-14C.

    Endocrine research communications·1982
    Same journal

    Evidence for cellular mediated immunity in an animal model of autoimmune pituitary disease.

    Endocrine research communications·1982
    Same journal

    The biological half-life of human growth hormone and a biologically active 20,000-dalton variant in mouse blood.

    Endocrine research communications·1982
    Same journal

    Conformational effects of ether bridge substitution in thyroid hormone analogues.

    Endocrine research communications·1982
    See all related articles

    Structural analysis of human luteinizing hormone (hLH) alpha subunit clarifies residue alignment. Minor amino-terminal heterogeneity in hLH contrasts with other glycoprotein hormones, possibly due to precursor cleavage differences.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Endocrinology

    Background:

    • Glycoprotein hormones share a common alpha subunit and hormone-specific beta subunit.
    • Amino acid sequence alignment, particularly residues 81-82 in the alpha subunit, remains debated.
    • N-terminal heterogeneity is observed in various alpha subunits, impacting structural understanding.

    Purpose of the Study:

    • To clarify the amino acid sequence alignment of residues 80-84 in the human luteinizing hormone (hLH) alpha subunit.
    • To investigate the extent and nature of N-terminal heterogeneity in the hLH alpha subunit.
    • To compare N-terminal heterogeneity patterns among different glycoprotein hormone alpha subunits.

    Main Methods:

    • Sequence analysis of the hLH alpha subunit.

    Related Experiment Videos

  • Comparison of hLH alpha subunit sequence with human follicle-stimulating hormone (hFSH) and human chorionic gonadotropin (hCG).

    • Main Results:

    • Residues 80-84 of the hLH alpha subunit were identified as -His-Cys-Ser-Thy-Cys-.
    • This sequence alignment is consistent with findings for hFSH and hCG alpha subunits.
    • hLH alpha subunit exhibits significantly less N-terminal heterogeneity compared to hFSH and hCG alpha subunits.

    Conclusions:

    • The study provides a precise sequence assignment for key residues in the hLH alpha subunit.
    • Differences in N-terminal heterogeneity among glycoprotein hormones may stem from variations in intracellular precursor peptide cleavage.
    • This research contributes to a clearer understanding of glycoprotein hormone structure and biosynthesis.