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The need for an alternative method to determine intravascular volumes
L M Lobigs1,2, P Peeling1,3, B Dawson1
1a School of Human Sciences (Exercise and Sports Sciences) , The University of Western Australia , Crawley , Australia.
European Journal of Sport Science
|June 19, 2018
Summary
Plasma volume (PV) changes affect blood markers like hemoglobin concentration ([Hb]), complicating health and doping tests. A new method using standard blood tests can now correct for these PV shifts, improving accuracy.
Area of Science:
- Exercise physiology
- Clinical biochemistry
- Sports science
Background:
- Environmental factors, notably exercise, significantly alter plasma volume (PV).
- Changes in PV complicate the interpretation of hematological markers measured as concentrations, such as hemoglobin ([Hb]).
- This poses challenges in clinical diagnostics and anti-doping efforts, where accurate assessment of hemoglobin mass (Hbmass) is crucial.
Purpose of the Study:
- To review the impact of plasma volume shifts on volumetric biomarkers, particularly [Hb].
- To highlight the need for methods to correct [Hb] for PV fluctuations.
- To examine novel approaches for calculating intravascular volumes and their applications.
Main Methods:
- Narrative review of existing literature on PV modulation by exercise.
- Quantification of PV variance impact on concentration-based markers.
- Discussion of methods for calculating intravascular volumes, focusing on a new biomarker panel approach.
Main Results:
- Endurance events characteristically induce progressive PV expansion.
- PV variations can lead to misinterpretation of [Hb] (e.g., pseudo-anemia vs. true anemia).
- A novel method utilizing standard blood test biomarkers offers a way to estimate PV.
Conclusions:
- Accurate assessment of hemoglobin mass requires accounting for plasma volume changes.
- A new blood test approach using descriptive biomarkers can correct for PV shifts.
- This method has significant potential applications in clinical settings and anti-doping analysis.
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