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Related Experiment Videos

Hyperpigmentation associated with oral minocycline

H A Ridgway, T S Sonnex, C T Kennedy

    The British Journal of Dermatology
    |July 1, 1982
    PubMed
    Summary

    Minocycline treatment can cause blue-black leg pigmentation due to iron-containing granules within macrophages. These granules may also contain minocycline degradation products, impacting skin histology.

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    Area of Science:

    • Dermatology
    • Histopathology
    • Toxicology

    Background:

    • Minocycline is an antibiotic used to treat various infections and inflammatory conditions.
    • Skin pigmentation is a known, though uncommon, side effect of minocycline therapy.

    Observation:

    • Two patients receiving minocycline presented with blue-black pigmentation on their legs.
    • Biopsies of the affected skin revealed the presence of pigment granules.

    Findings:

    • The granules contained iron, exhibiting staining properties similar to melanin.
    • A third, unidentified pigment, possibly a minocycline degradation product, was also observed.
    • Electron microscopy indicated that granules were primarily within macrophages, some being membrane-bound.
    • Analytical electron microscopy confirmed the presence of iron, sulfur, and chlorine within the granules, with calcium noted in one instance.

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    Implications:

    • This study elucidates the histopathological basis of minocycline-induced hyperpigmentation.
    • Understanding the composition of these pigment granules aids in diagnosing and managing this side effect.
    • Further research may clarify the exact nature of the minocycline degradation product and its role in pigmentation.