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Updated: Aug 18, 2026

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
Published on: September 16, 2020
Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals
Abstract:
Antipryine clearance was measured during occupational exposure and after an exposure-free interval of 3 wk in 26 spray painters, 44 workers in a herbicide-producing (phenoxyacids) plant, and 10 pesticide-exposed greenhouse gardeners. A control group of 39 workers were investigated simultaneously. A noninvasive simplified antipyrine clearance was used. Antipyrine clearance was greater in pesticide-exposed persons, but it was 15% less in workers exposed to spray paints compared to 3 wk after discontinuation of exposure. Clearance was unchanged in the control group examined at the same interval. Thus, the combined action of different spray paints, grinding dust, and cleaners may inhibit, and phenoxyacids, chlorophenols, and various pesticides may induce, the microsomal enzyme function. The workers had been exposed to the chemicals for years, but the change in antipyrine clearance apparently was reversible.
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