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Regional diffusing capacity in normal lungs during a slow exhalation

N R MacIntyre, J A Nadel

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1982
    PubMed
    Summary
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    This study measured lung diffusing capacity in different lung regions. Regional diffusing capacity remained stable during exhalation, suggesting consistent total lung function across mid-range lung volumes.

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Medicine

    Background:

    • Lung diffusing capacity is crucial for gas exchange.
    • Understanding regional variations in diffusing capacity is important for assessing lung health.

    Purpose of the Study:

    • To calculate regional diffusing capacity in the upper and lower lung halves.
    • To determine if regional diffusing capacity changes during exhalation.

    Main Methods:

    • Analysis of carbon monoxide uptake and xenon-133 distribution.
    • Two bolus inhalations in five seated normal subjects.
    • Calculation of regional diffusing capacity during the middle 60% of exhaled vital capacity.

    Main Results:

    • Regional diffusing capacity in the upper lungs was 11.6 ml.min-1.Torr-1.

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  • Regional diffusing capacity in the lower lungs was 24.4 ml.min-1.Torr-1 at 25% exhaled vital capacity.
  • These values remained constant as lung volume decreased from 25% to 75% of exhaled vital capacity.

    • Conclusions:

    • Total lung diffusing capacity is relatively constant over a mid-range of lung volumes.
    • This constancy is due to stable regional diffusing capacities in both upper and lower lung regions.