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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

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Related Experiment Video

Updated: Jul 14, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Giant pseudopolyposis in colitis with colonic intussusception

K A Forde, R P Gold, S Holck

    Gastroenterology
    |December 1, 1978
    PubMed
    Summary

    Giant pseudopolyps causing intussusception in ulcerative colitis necessitate surgery. Double contrast barium enema and colonoscopy are key diagnostic tools for this condition.

    Area of Science:

    • Gastroenterology
    • Colorectal Surgery
    • Diagnostic Imaging

    Background:

    • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
    • Giant pseudopolyps can develop as a complication of UC.
    • Intussusception is a rare but serious complication of pseudopolyp formation in UC.

    Observation:

    • A patient with known ulcerative colitis presented with intussusception.
    • The intussusception was caused by an area of giant pseudopolyp formation.
    • Surgical intervention was deemed necessary for this patient.

    Findings:

    • Double contrast barium enema proved valuable in diagnosing the intussusception and pseudopolyps.
    • Fiberoptic colonoscopy provided complementary diagnostic information.

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    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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    Last Updated: Jul 14, 2026

    Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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    Published on: October 16, 2013

    A Mouse Model of Intestinal Partial Obstruction
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    A Mouse Model of Intestinal Partial Obstruction

    Published on: March 5, 2018

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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  • These imaging modalities aided in the pre-operative evaluation.

    • Implications:

    • Accurate diagnosis of intussusception in UC patients is crucial for timely surgical management.
    • Multimodal diagnostic imaging, including barium enema and colonoscopy, enhances diagnostic accuracy.
    • Understanding the role of pseudopolyps in UC complications can improve patient outcomes.