Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Inflammatory Bowel Disease I: Introduction

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Differentiating familial Mediterranean fever attacks from acute appendicitis in children: which laboratory parameters are useful?

Scandinavian journal of rheumatology·2025

Same author

Report of Two Deaths from Partial Chloroform-Anæsthesia, with Remarks.

Daniel's Texas medical journal·2023

Same author

A decade of system- and population-based osteoporosis care improvement.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011

Same author

The veterinary status of Greece and UNRRA aid in 1945.

Journal of the American Veterinary Medical Association·2010

Same author

UNRRA livestock importation problems in Greece.

Veterinary medicine·2010

Same author

Triple therapy for patients with primary biliary cirrhosis with progressive disease despite ursodeoxycholic acid: another step forward.

Gastroenterologie clinique et biologique·2010

Search research articles

Related Experiment Video

Updated: May 20, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Diffuse ischemic colitis associated with systemic lupus erythematosus--response to subtotal colectomy

M G Kistin, M M Kaplan, J T Harrington

Gastroenterology

|December 1, 1978

Summary

Systemic lupus erythematosus (SLE) can cause severe gastrointestinal issues like universal colitis, leading to emergency surgery. A colectomy successfully treated massive rectal bleeding in a young woman with SLE, with no recurrence for two years.

More Related Videos

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Related Experiment Videos

Last Updated: May 20, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

Gastroenterology
Rheumatology
Vascular Medicine

Background:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organ systems.
Gastrointestinal manifestations of SLE are uncommon but can be severe and life-threatening.
This case highlights a rare but critical presentation of SLE-induced colitis.

Observation:

A 26-year-old woman with known SLE presented with massive, medically refractory rectal bleeding.
Diagnostic imaging and proctoscopy revealed universal colitis.
The patient's clinical condition rapidly deteriorated, necessitating emergency surgical intervention.

Findings:

Emergency subtotal colectomy was performed due to the patient's critical state.
Pathological examination of the resected colon showed gangrene, ischemic ulcerations, and fibrinoid vasculitis.
These findings were characteristic of SLE-induced vasculitis affecting the large intestine.

Implications:

Surgical management, specifically colectomy, can be a life-saving option for severe SLE-related gastrointestinal complications.
Early recognition of SLE-induced vasculitis in the gastrointestinal tract is crucial for timely intervention.
This case underscores the importance of considering SLE in the differential diagnosis of severe colitis, even in young patients.