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[Effects of furosemide on renal functions in prematures (author's transl)]
Insights
Furosemide significantly increased urine output and sodium excretion in preterm infants with respiratory distress syndrome. The drug also enhanced renal hydrogen elimination, suggesting a role beyond diuresis.
Area of Science:
- Neonatal Physiology
- Pharmacology
- Nephrology
Context:
- Preterm infants with respiratory distress syndrome (RDS) often experience fluid and electrolyte imbalances.
- Early-life diuretic use in neonates requires careful consideration of renal function.
- Respiratory distress syndrome impacts multiple organ systems, including the kidneys.
Purpose:
- To investigate the renal effects of Furosemide in preterm infants with respiratory distress syndrome within the first 2-4 days of life.
- To analyze changes in diuresis, sodium excretion, and glomerular filtration rate following Furosemide administration.
- To evaluate the impact of Furosemide on renal hydrogen-ion excretion and acid-base balance.
Summary:
- Furosemide administration led to a sevenfold increase in diuresis in preterm infants with RDS.
- This diuresis was attributed to increased sodium excretion and glomerular filtration.
- Furosemide also significantly increased urinary bicarbonate, titratable acidity, ammonium excretion, net acid excretion, and hydrogen clearance, indicating a role in renal hydrogen elimination.
Impact:
- Furosemide demonstrates a significant diuretic effect in preterm infants with RDS.
- The drug influences both sodium and water handling by the kidneys.
- Furosemide appears to play a role in renal acid-base regulation by enhancing hydrogen elimination.
Abstract:
Renal effects of Furosemide were examined during the first 2-4 days of life in preterm infants suffering from respiratory distress syndrome. Administration of the drug was followed by a sevenfold increase of diuresis. This latter was a result of both a rise in sodium excretion and glomerular filtration. The possible mechanism of Furosemide induced alteration in the glomerular filtration is discussed. Furosemide also altered the hydrogen-ion excretion: both the urinary bicarbonate, the titratable acidity and the ammonium excretion increased. There was a significant rise in the net acid excretion and hydrogen clearance too. It has been found that besides its diuretic effect Furosemide might play a role in the renal hydrogen elimination.