[Thermostability of inosine and its 8-substituted derivatives]

The derivatographic investigation of high temperature of inosine and its 8-substituted derivatives showed that the process of destruction involved 2 stages: low temperature endothermic decomposition at 120-220 degrees C without liberation of gaseous products (stage I) and high temperature exothermic decomposition to form water (stage II). The presence of electronegative 8-substituents in the inosine molecule made easier the cleavage of the N-glycoside link. This allows the conclusion that the reaction involved formation of intermediate ionic compounds based on ribose and hypoxanthine.