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Related Experiment Videos

Amiodarone-induced cornea verticillata

E Chew, M Ghosh, C McCulloch

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |June 1, 1982
    PubMed
    Summary

    Amiodarone, an antiarrhythmic drug, caused a typical keratopathy in most patients, often without symptoms. This drug-induced lipidosis affects the corneal epithelium and stroma, resembling other conditions.

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    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Cell Biology

    Background:

    • Amiodarone is a widely used antiarrhythmic medication.
    • Ocular side effects of amiodarone are known but often asymptomatic.
    • Corneal changes can mimic other lysosomal storage disorders.

    Purpose of the Study:

    • To investigate the incidence and characteristics of amiodarone-induced keratopathy.
    • To explore the ultrastructural pathology of this corneal condition.
    • To discuss the potential pathogenesis as a drug-induced lipidosis.

    Main Methods:

    • Clinical observation of 37 patients treated with amiodarone.
    • Ophthalmic examination for keratopathy.
    • Electron microscopy of corneal biopsy from one patient.

    Main Results:

    • 35 out of 37 patients developed a typical keratopathy.
    • The keratopathy was asymptomatic in all affected patients.
    • Electron microscopy revealed membrane-bound lamellar bodies in corneal epithelium and stromal keratocytes.

    Conclusions:

    • Amiodarone frequently induces asymptomatic keratopathy.
    • The corneal changes suggest a drug-induced lipidosis.
    • Pathogenesis may involve accumulation of lipid-like material in corneal cells.

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