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Middle molecular substances in acute renal failure
International Urology and Nephrology
|January 1, 1982
Summary
Middle molecular substances (MMS) accumulate during acute renal failure, peaking in the oliguric phase. These substances correlate with urea and creatinine levels, contributing to uremic syndrome.
Area of Science:
- Nephrology
- Biochemistry
- Clinical Medicine
Background:
- Middle molecular substances (MMS) are implicated in the pathogenesis of uremic syndrome.
- Understanding MMS dynamics is crucial for managing acute renal failure (ARF).
Purpose of the Study:
- To investigate the concentration changes of MMS in patients with ARF.
- To explore the relationship between MMS fractions and key uremic markers.
Main Methods:
- Gel filtration on Sephadex G 15 was used to analyze MMS.
- Plasma MMS concentrations were measured in 13 ARF patients across different phases.
Main Results:
- MMS levels significantly increased during the oliguric phase of ARF compared to controls.
- MMS concentrations remained elevated in the diuretic and convalescent phases.
- Specific MMS fractions (5 and 6) correlated with serum urea during the oliguric phase.
- Fraction 4 correlated with serum urea and creatinine during the diuretic phase.
Conclusions:
- MMS play a role in the development of uremic syndrome in acute renal failure.
- MMS levels fluctuate with the phases of ARF, indicating their dynamic involvement.