Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CO concentration-dependent changes in pulmonary diffusing capacity in humans

A Sybert, R Ayash, M Chatham

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits.

    Journal of applied toxicology : JAT·1998
    Same author

    Postexposure treatment with aminophylline protects against phosgene-induced acute lung injury.

    Experimental lung research·1997
    Same author

    Nitric oxide and prostaglandins mediate vasodilation to 5,6-EET in rabbit lung.

    Advances in experimental medicine and biology·1997
    Same author

    Intratracheal administration of DBcAMP attenuates edema formation in phosgene-induced acute lung injury.

    Journal of applied physiology (Bethesda, Md. : 1985)·1996
    Same author

    Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits.

    American journal of respiratory and critical care medicine·1995
    Same author

    Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors.

    Journal of applied physiology (Bethesda, Md. : 1985)·1993
    Same journal

    Metabolic control of cardiac output response to exercise in McArdle's disease.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Hypoxic insomnia: effects of carbon monoxide and acclimatization.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Quiet-breathing vs. panting methods for determination of specific airway conductance.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    A new method for raising neonatal rabbits in a hypoxic environment.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Modification of the cutaneous vascular response to exercise by local skin temperature.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Temperature regulation during treadmill exercise in the rat.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    See all related articles

    Pulmonary diffusing capacity for carbon monoxide (DLCO) in humans shows saturation kinetics, peaking at 100 ppm CO. This suggests carrier-mediated transport of CO in the lungs, similar to findings in dogs.

    Area of Science:

    • Physiology
    • Respiratory Medicine
    • Biophysics

    Background:

    • Pulmonary diffusing capacity for carbon monoxide (DLCO) is a key measure of lung function.
    • Understanding the transport mechanisms of carbon monoxide (CO) in the lungs is crucial for respiratory physiology.
    • Previous studies suggested carrier-mediated transport, but further evidence in humans during exercise was needed.

    Purpose of the Study:

    • To investigate the relationship between inspired CO concentration and DLCO during light exercise in humans.
    • To determine if CO transport in the human lung exhibits saturation kinetics.
    • To provide evidence for or against carrier-mediated transport of CO in human lungs.

    Main Methods:

    • Steady-state DLCO was measured in eight participants (seven males, one female) during light treadmill exercise.

    Related Experiment Videos

  • Inspired CO concentrations were varied.
  • End-tidal CO concentrations were monitored.

    • Main Results:

    • DLCO increased with rising inspired CO concentrations, reaching a maximum at approximately 100 ppm end-tidal CO.
    • At peak levels, DLCO was up to twice as high as at a high inspired CO concentration (approx. 1,780 ppm).
    • The observed relationship between DLCO and CO concentration is consistent with saturation kinetics.

    Conclusions:

    • Human lung CO transport exhibits saturation kinetics, supporting carrier-mediated transport.
    • These findings in humans align with previous observations in mechanically ventilated dogs.
    • Evidence suggests a carrier-mediated mechanism for CO transport in both human and canine lungs.