Colorimetric determination of ethambutol hydrochloride
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Abstract:
A precise colorimetric procedure is proposed for estimation of ethambutol hydrochloride, based on reaction of the drug with 2,4-dinitro-1-fluorobenzene under stipulated conditions. The yellow chromophore is quantitated spectrophotometrically at 376 +/- 1 nm. The relationship between absorbance and drug concentration was linear within a range of 5-40 micrograms/mL. The method is suitable for the analytical control of ethambutol HCl and its formulations.
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