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Related Experiment Videos

Monocyte function in cirrhosis

G Holdstock, B Leslie, S Hill

    Journal of Clinical Pathology
    |September 1, 1982
    PubMed
    Summary
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    Monocyte immune cell function is impaired in cirrhosis patients, showing reduced bacterial defense. This defect is caused by a circulating inhibitor, potentially explaining increased infection risk in these individuals.

    Area of Science:

    • Immunology
    • Hepatology
    • Cell Biology

    Background:

    • Cirrhosis is associated with increased susceptibility to infections.
    • Monocyte dysfunction may contribute to impaired host defense in liver disease.

    Purpose of the Study:

    • To investigate monocyte function in patients with biopsy-proven cirrhosis.
    • To identify potential factors contributing to monocyte abnormalities in cirrhosis.

    Main Methods:

    • Assessed monocyte spreading, chemotaxis, phagocytosis, and bacterial killing in 51 cirrhosis patients and 35 controls.
    • Measured lysosomal enzyme production and nitro-blue tetrazoline (NBT) reduction in monocytes.
    • Investigated the effect of patient serum and portal/systemic serum on monocyte function.

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    Main Results:

    • Cirrhotic patients exhibited significantly reduced monocyte spreading, chemotaxis, phagocytosis, and bacterial killing compared to controls.
    • Monocytes from cirrhosis patients produced lower levels of N-acetyl beta-glucosaminidase and beta-glucuronidase.
    • A circulating inhibitory factor in cirrhotic serum was identified, which impaired monocyte function but could be corrected by control serum.

    Conclusions:

    • Monocyte function is significantly impaired in patients with cirrhosis.
    • A serum-borne inhibitor, possibly originating from the portal vein, is responsible for the reduced monocyte activity.
    • These monocyte abnormalities may contribute to the increased risk of infection observed in cirrhosis.