Peripheral microcystoid retinal degeneration and retinoschisis

Peripheral microcystoid retinal degeneration and degenerative retinoschisis represent two findings frequently made during indirect ophthalmoscopy of the peripheral fundus. Peripheral microcystoid degeneration, a benign condition, may represent a precursor to degenerative retinoschisis, a potentially sight threatening condition. Discussed are the epidemiology, histologic and clinical appearance, and possible pathogenesis of each. The normal progression of both conditions, together with the prognostic value of inner and/or outer layer holes in degenerative retinoschisis are addressed. Methods of following degenerative retinoschisis and modes of treatment of progressive cases are considered.