Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioral, compound action potential, and single unit thresholds: relationship in normal and abnormal ears

P Dallos, D Harris, O Ozdamar

    The Journal of the Acoustical Society of America
    |July 1, 1978
    PubMed
    Summary

    This study compared auditory thresholds in chinchillas and gerbils. Action potential thresholds closely predict behavioral audiograms, especially in cases of hair cell loss from Kanamycin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PROfessionalism in Partnership for Education Research (PROPER) study: a novel online initiative approach to professionalism education.

    BMC medical education·2026
    Same author

    The effect of concentrate crude protein concentration and replacing imported feed ingredients with locally grown cereals and faba bean on milk production and nitrogen utilization in grazing dairy cows.

    Journal of dairy science·2026
    Same author

    Clival metastasis presenting with oculomotor nerve palsy in a patient with a prior history of breast cancer.

    Irish medical journal·2025
    Same author

    The Stable Acute Vertebral (SAVe) compression fracture study.

    Irish medical journal·2024
    Same author

    Expanded carrier screening for inherited genetic disease using exome and genome sequencing.

    Journal of genetic counseling·2024
    Same author

    A randomized single-blinded prospective study comparing simulated daylight photodynamic therapy with natural daylight photodynamic therapy for multiple actinic keratoses.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2024

    Area of Science:

    • Auditory Neuroscience
    • Comparative Physiology
    • Sensory Biology

    Background:

    • Understanding the relationship between physiological auditory responses and behavioral hearing ability is crucial for diagnosing hearing loss.
    • Action potentials (AP) and single-fiber responses are key physiological measures of auditory function.
    • Behavioral audiograms reflect an organism's overall hearing sensitivity.

    Purpose of the Study:

    • To compare behavioral audiograms with physiological auditory measures (action potential and single-fiber thresholds) in chinchillas and mongolian gerbils.
    • To determine if physiological measures can predict behavioral hearing thresholds, particularly in cases of induced hearing damage.
    • To investigate the relationship between these measures across different frequencies.

    Main Methods:

    Related Experiment Videos

    • Auditory thresholds were measured using behavioral audiograms and electrophysiological recordings (action potentials and single-fiber responses) in response to tone bursts.
    • Data were collected from normal chinchillas, Kanamycin-treated chinchillas, and Kanamycin-treated gerbils.
    • Responses were averaged in one-octave bands and analyzed for relationships across frequency ranges.

    Main Results:

    • A well-ordered relationship was observed between mean behavioral audiogram, action potential (AP) thresholds, and single-fiber response thresholds.
    • AP and unit thresholds were consistently within 10 dB of each other across frequencies.
    • Behavioral thresholds were generally more sensitive (15-20 dB) but showed parallel trends, diverging at higher frequencies.

    Conclusions:

    • Action potential thresholds serve as reliable predictors of behavioral hearing threshold configurations in both normal and Kanamycin-intoxicated animals.
    • The close correlation between physiological and behavioral measures supports their use in assessing hearing function and damage.
    • This study highlights the utility of electrophysiological measures in understanding auditory perception.