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Related Experiment Videos

Tack behavior of coating solutions I

S K Chopra, R Tawashi

    Journal of Pharmaceutical Sciences
    |August 1, 1982
    PubMed
    Summary

    Tablet coating tackiness was measured using a tensile tester. Higher separation rates and viscosity increased tackiness, with a non-linear relationship between tack and viscosity proposed.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Tablet coatings are crucial for drug delivery and stability.
    • Understanding the physical properties of coating solutions, like tackiness, is essential for manufacturing.

    Purpose of the Study:

    • To quantify the tackiness of tablet coating solutions.
    • To investigate the influence of separation rate and viscosity on tackiness.

    Main Methods:

    • Utilized a parallel plate technique with a tensile testing machine.
    • Measured separation force as a function of time using an oscilloscope.
    • Evaluated liquid films of constant thickness at various separation rates.

    Main Results:

    • The force required to split liquid films increased with higher rates of separation.
    • Tablet coating tackiness demonstrated a positive correlation with increased viscosity.
    • The relationship between tackiness and viscosity was found to be non-linear.

    Conclusions:

    • Separation rate and viscosity are key factors influencing tablet coating tackiness.
    • A modified Stefan equation was proposed to describe the observed tack-viscosity relationship.

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