[The hemostatic system in acute occlusion of the major arteries]

The system of the haemostasis in acute occlusion of the main arteries is characterized by a combination of hypercoagulation, arrest of fibrinolysis, and increase of the adhesive-aggregation function of the formed elements of the blood. The age, aetiology, localisation and the character of arterial occlusion, the degree, and the duration of ischaemia of the tissues influence the degree of the above disorders. The above factors must be taken into consideration in choosing methods of the antithrombotic therapy of thromboembolic lesions of the main arteries. The main principle of such therapy is simultaneous corrections of the disorders of haemocoagulation, fibrinolysis, adhesion, and aggregation of the formed elements of the blood by the combined use of anticoagulants, fibrinolytic and antiaggregation drugs.