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Related Experiment Videos

Anaerobic corneal ulcers

L D Perry, J H Brinser, H Kolodner

    Ophthalmology
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Anaerobic bacteria can cause serious corneal ulcers, often with predisposing factors. Most anaerobic isolates were susceptible to common antibiotics, with chloramphenicol recommended for treatment.

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    Area of Science:

    • Ophthalmology
    • Microbiology

    Background:

    • Bacterial keratitis is a significant cause of vision loss.
    • Anaerobic bacteria are less commonly recognized causes of corneal ulcers.

    Purpose of the Study:

    • To identify the prevalence and characteristics of anaerobic bacterial keratitis.
    • To determine predisposing factors and effective treatments for anaerobic corneal ulcers.

    Main Methods:

    • Retrospective analysis of 162 bacterial corneal ulcers.
    • Strict microbiologic criteria for confirming anaerobic infection.
    • Identification of anaerobic isolates and antibiotic susceptibility testing.

    Main Results:

    • 11 of 162 ulcers (6.8%) were confirmed anaerobic bacterial keratitis.

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  • Predisposing factors were present in all anaerobic ulcer patients.
  • Five new anaerobic strains were identified as causes of keratitis.
  • Most anaerobic isolates showed susceptibility to routine antibiotics.

    • Conclusions:

    • Anaerobic bacteria are an underrecognized cause of bacterial keratitis.
    • Topical chloramphenicol is recommended for confirmed anaerobic ulcers.
    • Broad-spectrum antibiotics including cephalosporins effective against anaerobes are advised for all severe ulcers.