[Electron microscopic study of the genome homology of simian adenoviruses]

DNA homologies of simian adenoviruses SA7, SV20, SV30, SV38, and SA7(C8), clone 230, were studied. The genomes of SV20, SV30, and SV38 differ from each other insignificantly (at least 85% of homology), but from the SA7 genome significantly (50-70% of homology). DNAs of SV20, SV30, and SV38 contain four main regions of melting in 90% formamide: two terminal A-T-rich regions are located symmetrically on the termini of the molecules, and two on the right parts of the molecules. SA7 virus DNA differs from that of the three above-mentioned viruses by the A-T composition and contains only two regions of melting on the right part of the molecule under similar denaturating conditions. SV20, SV30, and SV38 DNAs contain the inverted terminal repetitions of the order of 147 nucleotides long, and SA7 DNA contains considerably longer inverted terminal repetition: 230 nucleotides.