[Experimental induction of uterus tumours by modification of localised vascularization]

Present knowledge of aetiopathogenesis of uterus fibroma is based on clinical observation and backed up by pathologico-anatomic laboratory studies. In some cases, tumours were experimentally induced to animals by oestrogenic stimulation. -- The vascular factor was considered to be of minor and unspecific importance to fibroma genesis, in the context of findings so far obtained. Clinical observations, however, suggested that certain vascular disorders in genital organs provided predisposition to tumour development. Rheographic and pelvophlebographic investigations have shown that uterus fibroma has always been accompanied by pelvic congestion. - These insights prompted the authors to undertake experimental studies into the role played by the vascular factor in the genesis of uterus fibroma. Oestrogenic stimulation was used to induce uterus tumours in guinea pigs, following artificially generated vascular changes, such as ischaemia and stasis.