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Copper absorption in elderly men determined by using stable 65Cu

J R Turnlund, M C Michel, W R Keyes

    The American Journal of Clinical Nutrition
    |October 1, 1982
    PubMed
    Summary
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    This study measured copper absorption in elderly men, finding that lower dietary nitrogen intake slightly increased copper absorption. The absorbed copper was sufficient to maintain copper balance in this population.

    Area of Science:

    • Human Nutrition
    • Mineral Metabolism
    • Gerontology

    Background:

    • Copper is an essential trace element vital for numerous physiological processes.
    • Nutrient absorption and balance can change with age, particularly in elderly populations.
    • Dietary factors, such as protein (nitrogen) content, may influence mineral absorption.

    Purpose of the Study:

    • To determine the apparent absorption of copper in elderly men.
    • To investigate the effect of varying dietary nitrogen levels on copper absorption.
    • To assess if copper absorption is adequate to maintain copper balance in older adults.

    Main Methods:

    • Utilized the stable isotope 65Cu to trace copper absorption.
    • Analyzed copper isotopic ratios via thermal ionization, magnetic sector mass spectrometry.

    Related Experiment Videos

  • Separated copper from fecal samples using ion exchange chromatography.

    • Main Results:

    • Mean apparent copper absorption was 23.9% with higher nitrogen intake (9-19g) and 27.7% with lower nitrogen intake (4.0-5.7g).
    • Copper absorption was significantly higher (p<0.05) when dietary nitrogen was reduced.
    • Absorbed copper (0.8-0.9 mg/day) was sufficient to maintain copper balance in participants.

    Conclusions:

    • Elderly men appear to absorb adequate amounts of copper to maintain balance.
    • Reduced dietary nitrogen intake may enhance apparent copper absorption in elderly men.
    • Further research into dietary interactions influencing copper status in aging is warranted.