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Related Experiment Videos

Oxygen measurements: dynamic vs static conditions

W R Roscoe, R M Hill

    American Journal of Optometry and Physiological Optics
    |July 1, 1982
    PubMed
    Summary

    Equivalent oxygen percentage (E.O.P.) responses differed significantly between open and closed eyes with Permalens contact lenses. This finding has clinical implications for extended wear contact lens patients.

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    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Corneal Physiology

    Background:

    • Understanding oxygen supply to the cornea is crucial for contact lens wear.
    • Previous studies established baseline Equivalent Oxygen Percentage (E.O.P.) responses.
    • Permalens contact lenses are used for extended wear, necessitating evaluation of corneal oxygenation.

    Purpose of the Study:

    • To measure Equivalent Oxygen Percentage (E.O.P.) responses in a mammalian corneal model.
    • To compare E.O.P. responses under open-eye versus closed-eye conditions with Permalens contact lenses.
    • To investigate discrepancies in E.O.P. responses under closed-eye conditions.

    Main Methods:

    • Utilized a mammalian corneal model to assess E.O.P.
    • Measured E.O.P. responses under both open-eye and closed-eye conditions.
    • Incorporated the presence of a Permalens contact lens during measurements.

    Main Results:

    • E.O.P. responses under open-eye conditions aligned with existing data.
    • A significant difference in E.O.P. responses was observed under closed-eye conditions compared to previous findings.
    • The study identified a notable discrepancy in corneal oxygenation during closed-eye wear.

    Conclusions:

    • Permalens contact lens wear significantly alters corneal oxygenation in closed-eye conditions.
    • The observed E.O.P. differences under closed eyes warrant further investigation for extended wear safety.
    • Findings highlight the clinical significance of oxygen levels for extended wear contact lens patients.

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