Oxygen measurements: dynamic vs static conditions

Equivalent oxygen percentage (E.O.P.) responses, using a mammalian corneal model, were measured for open-and closed-eye conditions with the presence of a Permalens contact lens. Under open-eye conditions, the E.O.P. responses agreed with those measured or predicted by other investigators. However, under closed-eye conditions, the E.O.P. responses were significantly different from those measured or predicted by other investigators. This discrepancy is discussed in terms of its clinical significance for extended wear contact lens patients.