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[Breath test study of sucrose absorption in infants with acute diarrhea ]
Insights
Infants with acute diarrhea may experience temporary sucrose malabsorption, as shown by the Breath Test method (BTH). This transient condition does not preclude the use of sucrose solutions in treatment.
Area of Science:
- Pediatric Gastroenterology
- Digestive Physiology
- Nutritional Science
Context:
- Acute diarrhea is a common pediatric condition.
- Sucrose is frequently used in oral rehydration solutions.
- Assessing carbohydrate absorption is crucial for managing pediatric gastrointestinal disorders.
Purpose:
- To investigate sucrose absorption in infants with acute diarrhea using the Breath Test method (BTH).
- To determine the prevalence and nature of sucrose malabsorption during acute diarrheal episodes.
- To evaluate the implications of observed sucrose malabsorption for therapeutic interventions.
Summary:
- Sucrose absorption was assessed in 41 infants with acute diarrhea via the Breath Test method (BTH).
- Malabsorption was identified in 8 out of 28 infants receiving a 40% sucrose solution and in 9 out of 36 infants undergoing a sucrose loading test.
- The observed sucrose malabsorption was consistently transitory in all affected children.
Impact:
- The findings suggest that while sucrose malabsorption can occur during acute diarrhea, it is typically temporary.
- This transient malabsorption is unlikely to contraindicate the therapeutic use of sucrose-containing solutions in infants.
- The study highlights a difference in sucrose absorption patterns between acute and chronic diarrhea, even in cases of villous atrophy.
Abstract:
Sucrose absorption was studied by the Breath Test method (BTH) in 41 infants presenting with acute diarrhea. In 28, studies were performed in children treated orally with a 40% sucrose solution. Malabsorption was demonstrated in 8 cases. In 36 infants, sucrose loading test (1 g/kg) was carried out between the 3rd and the 7th days of the diarrhea: malabsorption was present in 9 cases. Malabsorption was transitory in all children. The frequency of this sucrose malabsorption during acute diarrhea is not sufficient to prevent the therapeutic use of sucrose solution, but differs from the usual lack of sucrose malabsorption in chronic diarrhea, even, as shown here, in children with complete villous atrophy.