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Related Experiment Videos

Aspirin stability in solid dispersion binary systems

H M El-Banna, N A Daabis, S A El-Fattah

    Journal of Pharmaceutical Sciences
    |November 1, 1978
    PubMed
    Summary

    Aspirin stability in solid dispersions with urea or povidone was studied. Urea and povidone accelerated aspirin decomposition, with temperature having a greater impact than humidity.

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    Area of Science:

    • Pharmaceutical Sciences
    • Solid State Chemistry

    Background:

    • Aspirin (acetylsalicylic acid) is a widely used analgesic and anti-inflammatory drug.
    • Solid dispersions are a promising formulation strategy to enhance drug solubility and stability.

    Purpose of the Study:

    • To investigate the solid-state stability of aspirin when formulated with urea or povidone.
    • To identify factors influencing aspirin degradation in these solid dispersion systems.

    Main Methods:

    • Investigated aspirin stability in solid dispersions with urea and povidone under accelerated storage conditions.
    • Analyzed degradation kinetics using the first-order rate equation.
    • Evaluated the influence of temperature and humidity.

    Main Results:

    • Aspirin degradation followed first-order kinetics in both urea and povidone systems.
    • Water sorption by carriers and urea's alkalinity accelerated aspirin decomposition.
    • Temperature had a more significant effect on degradation than humidity.
    • Coprecipitated samples showed slightly higher degradation rates than physically mixed samples.

    Conclusions:

    • Urea and povidone can influence aspirin stability in solid dispersions.
    • Formulation strategies should consider carrier properties like water sorption and pH.
    • Optimizing storage conditions, particularly temperature, is crucial for maintaining aspirin integrity.

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