Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thimerosal determination by high-pressure liquid chromatography

R C Meyer, L B Cohn

    Journal of Pharmaceutical Sciences
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correlates of HIV-1 control after combination immunotherapy.

    Nature·2025
    Same author

    Combination immunotherapy induces post-intervention control of HIV.

    Research square·2025
    Same author

    Experimental Peracute Colibacillosis: Gastrointestinal Lesions in Gnotobiotic Piglets.

    Veterinary pathology·2018
    Same author

    OPERATION FOR PITUITARY TUMOUR.

    British medical journal·2010
    Same author

    Natural developmental variations in leaf and plant senescence in Arabidopsis thaliana.

    Plant biology (Stuttgart, Germany)·2008
    Same author

    Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis.

    The Plant journal : for cell and molecular biology·2003
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    A new high-pressure liquid chromatography method accurately measures intact thimerosal. This fast, reliable, and specific technique offers a significant advancement over existing wet chemical analyses.

    Area of Science:

    • Analytical Chemistry
    • Environmental Science
    • Pharmacology

    Background:

    • Thimerosal is an ethylmercury-containing preservative.
    • Accurate quantification of thimerosal is crucial for safety and regulatory compliance.
    • Existing analytical methods for thimerosal can be time-consuming or lack specificity.

    Purpose of the Study:

    • To develop a sensitive and reliable method for determining intact thimerosal.
    • To establish a high-pressure liquid chromatographic (HPLC) technique for thimerosal analysis.
    • To provide a breakthrough analytical solution compared to conventional methods.

    Main Methods:

    • Development of a high-pressure liquid chromatography (HPLC) method.
    • Optimization of chromatographic conditions for thimerosal separation.

    Related Experiment Videos

  • Validation of the method for sensitivity, speed, and specificity.

    • Main Results:

    • A highly sensitive HPLC method for intact thimerosal determination was successfully developed.
    • The method demonstrated exceptional speed and reliability.
    • The inherent specificity of the HPLC method was confirmed, surpassing common wet chemical techniques.

    Conclusions:

    • The developed HPLC method is a sensitive, fast, and reliable tool for quantifying intact thimerosal.
    • This technique represents a significant improvement over existing analytical approaches.
    • The method's specificity ensures accurate measurement, crucial for various applications.