Spontaneous regression of bilateral retinoblastoma

A 24-year-old black man was found to have bilateral, spontaneously regressed retinoblastoma that had previously been misdiagnosed as post-traumatic chorioretinal scarring. His son and half-brother both had bilateral viable retinoblastoma. The ophthalmoscopic and fluorescein angiographic features of this patient's fundus lesions included a calcified, whitish mass located centrally in one of the scars and a fine residual vascularity in another of the fundus lesions. The authors review the pertinent literature on spontaneous regression of retinoblastoma.