[Model of regulating blood glucose level during physical load]

A mathematical model has been developed for studying the dynamics of blood glucose and lactate under physical load. The model describes the Cori cycle and glycogen metabolism in the liver and skeletal muscle. It takes account of both the activation of liver gluconeogenesis (GNG) and of its inhibition due to a low pH caused by high lactate concentrations. The system behavior pattern following the transition from rest to load is demonstrated by stepped variation of the load parameter. The model provides an explanation of smaller changes in glycemia in the trained persons.