[Neurospecific antigen D in the postnatal ontogeny of rat brain structures]

The time course of antigen D similar to well-known neurospecific proteins 14-3-2 and antigen alpha was studied during postnatal ontogenesis of brain structures of Wistar rats: Cross immunoelectrophoresis was made use of to measure the content of antigen D in the visual cortex, hippocamp and nucleus caudatus of rats aged 7, 14, 21 and 30 days and 1 year. Changes in the levels of two antigen D components, slow- and fast-migrating (SMC and FMC) were recorded to show that their content in the test structures increased most intensely from the 14th to the 21st day of postnatal development. In all the brain structures of tendency was recorded towards the increased SMC/FMC ratio during postnatal ontogenesis, that may point to an important role of FMC for bain functions in maturing and adult animals.