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The structural proteins of rabies virus

J H Cox

    Comparative Immunology, Microbiology and Infectious Diseases
    |January 1, 1982
    PubMed

    Insights

    Rabies virus structural proteins were re-evaluated. The M1 protein is now NS, and M2 is the M protein, reflecting their roles in the nucleocapsid and viral membrane.

    Area of Science:

    • Virology
    • Molecular Biology

    Background:

    • Rabies virus possesses five structural proteins: L, G, N, M1, and M2.
    • Previous classifications require re-evaluation based on new findings.

    Purpose of the Study:

    • To re-evaluate the roles and nomenclature of rabies virus structural proteins.
    • To propose updated names for M1 and M2 proteins based on their functions.

    Main Methods:

    • Analysis of recent experimental results concerning rabies virus protein associations.
    • Localization studies of viral proteins in infected cells.

    Main Results:

    • The M1 protein is part of the nucleocapsid complex with N, L proteins, and RNA.
    • Only G and M2 proteins were detected on the surface of infected cells.
    • M2 is identified as the sole membrane protein.

    Conclusions:

    • The M1 protein should be renamed NS, similar to vesicular stomatitis virus.
    • The M2 protein should be renamed M, reflecting its membrane localization.

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