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The structural proteins of rabies virus
Comparative Immunology, Microbiology and Infectious Diseases
|January 1, 1982
Summary
Rabies virus structural proteins were re-evaluated. The M1 protein is now NS, and M2 is the M protein, reflecting their roles in the nucleocapsid and viral membrane.
Area of Science:
- Virology
- Molecular Biology
Background:
- Rabies virus possesses five structural proteins: L, G, N, M1, and M2.
- Previous classifications require re-evaluation based on new findings.
Purpose of the Study:
- To re-evaluate the roles and nomenclature of rabies virus structural proteins.
- To propose updated names for M1 and M2 proteins based on their functions.
Main Methods:
- Analysis of recent experimental results concerning rabies virus protein associations.
- Localization studies of viral proteins in infected cells.
Main Results:
- The M1 protein is part of the nucleocapsid complex with N, L proteins, and RNA.
- Only G and M2 proteins were detected on the surface of infected cells.
- M2 is identified as the sole membrane protein.
Conclusions:
- The M1 protein should be renamed NS, similar to vesicular stomatitis virus.
- The M2 protein should be renamed M, reflecting its membrane localization.