Temperature dependence of morphological response of glioblasts to glia maturation factor

Glioblasts respond to glia maturation factor (GMF) by outgrowth of cell processes. This morphological response takes place at 37 degrees C but not at 23 degrees C, suggesting the involvement of temperature-dependent chemical processes in the mechanism of action of GMF. The morphological response of glioblasts to GMF is correlated with the rearrangement of microtubules but not with any net change in tubulin content of the cells.