[Effect of guanclofin on catecholamine release by the adrenal medulla]

The influence of guanoclofine, an adrenergic neurone-blocking agent, on catecholamine release from isolated perfused bovine adrenal glands was studied. Guanclofine inhibited the amine liberation induced by carbachol, aminophylline, prenylamine, and snake venoms. Guanoxane and guanethidine at equimolar concentrations were less effective. The inhibitory effect of guanclofine is assumed to be due to a nonspecific effect on the cell membrane.