[Pharmacokinetics of hydrazine sulfate in intact and tumor-bearing rats]

The pharmacokinetics of hydrazine sulfate was studied in intact and tumor-bearing (sarcoma 45) random-bred rats after intraventricular administration of the drug. To determine hydrazine in biosubstrates, a method was devised, which is based on spectrophotometry of the coloured product formed as a result of interaction with p-dimethylaminobenzaldehyde. Analysis of the pharmacokinetic data with the use of a 4-compartmental model showed appreciable differences in some of the pharmacokinetic parameters of hydrazine sulfate as regards intact and tumor-bearing animals.