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Updated: Sep 7, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Chronic anicteric intrahepatic cholestasis associated with ankylosing spondylitis. Beneficial treatment by clofibrate
Abstract:
A case of anicteric idiopathic intrahepatic cholestasis in association with ankylosing spondylitis is described. No primary cause for the cholestatic syndrome was found and the liver histology was repeatedly normal. Results of treatment with clofibrate (2 g daily) were very satisfactory, as the symptoms and signs of cholestasis had gradually subsided. Discontinuation of the treatment was followed rapidly by a recurrence of the cholestasis with a new improvement after restarting treatment. The beneficial mechanism of action of clofibrate on the intrahepatic cholestasis in the case described remains speculative.
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