In vivo endocrine studies and morphological features in a case of hilus cell tumor in mesovarium

In a 38-year-old white woman with a virilizing mesovarium hilus cell tumor and polycystic ovaries, serum levels of 13 hormones were measured under different conditions. Endocrine studies showed that testosterone was the principal secretory product of tumor cells. Androstenedione, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate were normal. Light and electron microscopic investigations of the tumor showed polygonal cells containing intracytoplasmic Reinke crystalloids. Immunoperoxidase studies demonstrated the presence of testosterone within tumor cells.