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Related Experiment Videos

Complexation of procainamide with dextrose

V D Gupta

    Journal of Pharmaceutical Sciences
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Procainamide complexation with dextrose depends on dextrose concentration and solution pH. This reversible process is unaffected by salt additions but is inhibited by hydrochloric acid, which also breaks the complex.

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    Area of Science:

    • Pharmaceutical Chemistry
    • Physical Chemistry
    • Chemical Engineering

    Background:

    • Procainamide is an antiarrhythmic drug.
    • Understanding drug-excipient interactions is crucial for formulation development.

    Purpose of the Study:

    • To investigate the complexation of procainamide with dextrose.
    • To determine the factors influencing this complexation process.

    Main Methods:

    • Spectrophotometric analysis to quantify procainamide-dextrose complex.
    • Varying concentrations of dextrose and procainamide.
    • Adjusting solution pH using hydrochloric acid.
    • Addition of sodium chloride and edetate disodium.

    Main Results:

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    • Complexation is directly proportional to dextrose concentration.
    • The process is reversible and pH-dependent, ceasing below pH 1.5.
    • Initial pH affects complex formation rate; pH decreases with increasing complex concentration.
    • Procainamide concentration does not alter equilibrium complex concentration.
    • Sodium chloride and edetate disodium do not impact complexation rate or equilibrium.
    • Hydrochloric acid addition prevents complex formation and dissociates existing complexes.

    Conclusions:

    • Dextrose concentration and initial pH are key factors in procainamide complexation.
    • The complexation is reversible and sensitive to acidic conditions.
    • Formulation strategies should consider pH control for procainamide-dextrose systems.