Antibody formation after vaccination with adsorbed and non-adsorbed A/New Jersey/8/76 influenza vaccines

A study was carried out to determine the titres of haemagglutination inhibiting and neuraminidase antibodies after vaccination of 90 subjects, aged 19 to 35 years, with three aluminium oxide adsorbate and three fluid monovalent influenza A/New Jersey/8/76 vaccines with 54, 108 and 216 IU/dose. Blood samples were taken 1, 3 and 6 months after vaccination. The serological findings showed that adsorbate vaccines induced higher antibody titres than did fluid vaccines with double the antigen content. 'Unprimed persons' reacted to the adsorbate vaccine vaccination with a much higher antibody formation response.