[Toxicological evaluation of "Farmakhim" thiabendazole in mammals and birds]

Studied were the acute toxicity (albino mice and rats, chicken broilers), species specific tolerance (lambs, sheep, goats, pigs, calves, chicks, chickens), and subchronic toxicity (albino rats, pigs, pulets) of tiabendazole Pharmachim (TP). It was found that LD50 of TP at the oral application to albino mice, weighing 18-20 g was 2.7 g (2.14 divided by 3.40) per kg for albino rats weighing 120-200 g it proved technically undeterminable. For broilers at one month it was 4.0 g (2.54 divided by 6.28) per kg. LD50 of TP of the firm Merck Sharp and Dome for albino mice was 2.9 g (2.28 divided by 3.68), and for broilers -- 5.0 g (4.31 divided by 5.8) per kg. The lethal dose for lambs was 400 mg/kg, for sheep -- 800 mg/kg, for goats -- 500 mg/kg, and for calves -- 500 mg/kg. When treated with amounts of 450 and 850 mg/kg pigs vomited. The same was true of drugs when offered the preparation at the rate of 300 mg/Kg chicks and chickens tolerated amounts of 500 mg/kg. TP was well tolerated by pigs, rats, and pullets when given with the feed for 30 days in 0.1 per cent conc.; in 0.4% conc. (pigs), 0.5% (albino rats), 0.3% (pullets), and 1% (albino rats and pullets) led to the arrest of growth and rise of transaminases and urea in the blood serum (rats and pigs) and the adverse effect of the red blood picture (rats, pigs, and pullets). Histologically, there were vascular troubles and granular degeneration that predominated in the kidneys, and were more slightly expressed in the remaining parenchymal organs.