Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Circulating immune complexes and age]

F Hiepe, E Apostoloff, E Döring

    Zeitschrift Fur Alternsforschung
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Refractory mixed proliferative and membranous lupus nephritis treated with the topoisomerase I inhibitor irinotecan as add-on therapy.

    Scandinavian journal of rheumatology·2021
    Same author

    Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study.

    The Journal of antimicrobial chemotherapy·2021
    Same author

    [Autologous hematopoietic stem cell transplantation for autoimmune diseases : Current indications and mode of action, a review on behalf of the EBMT Autoimmune Diseases Working Party (ADWP)].

    Zeitschrift fur Rheumatologie·2020
    Same author

    [Autologous hematopoietic stem cell transplantation for systemic sclerosis : Position statement of the stem cell therapy working party of the German Society of Rheumatology].

    Zeitschrift fur Rheumatologie·2020
    Same author

    Enzyme autoinduction by mitotane supported by population pharmacokinetic modelling in a large cohort of adrenocortical carcinoma patients.

    European journal of endocrinology·2018
    Same author

    [Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus].

    Zeitschrift fur Rheumatologie·2016
    Same journal

    [Changes in dendrites in disease and aging].

    Zeitschrift fur Alternsforschung·1989
    Same journal

    [The significance of thrombolytic therapy in acute myocardial infarct in advanced age].

    Zeitschrift fur Alternsforschung·1989
    Same journal

    [Response to the contribution by M. von Ardenne: "The energetic fate of the human and its favorable modification by multiphase oxygen therapy"].

    Zeitschrift fur Alternsforschung·1989
    Same journal

    [Supplementary references on the contribution by J. Schultz and K. Mascher. "Differential therapeutic aspects of pneumonia in the elderly"].

    Zeitschrift fur Alternsforschung·1989
    Same journal

    [How homogenous are clinical samples? Comments on the contribution by Raissa S. Jazemirskaja: Multi-infarct dementia in very elderly patients].

    Zeitschrift fur Alternsforschung·1989
    Same journal

    [Multi-infarct dementia in the very elderly].

    Zeitschrift fur Alternsforschung·1989
    See all related articles

    Healthy adults aged 0-15 years have the lowest circulating immune complexes. Immune complex levels show minor variations across other adult age groups, with no significant sex-based differences observed.

    Area of Science:

    • Immunology
    • Clinical Chemistry

    Context:

    • Circulating immune complexes (CICs) play a role in immune homeostasis and disease.
    • Quantifying CICs in healthy populations provides a baseline for understanding immune function.

    Purpose:

    • To quantitatively determine CIC levels in healthy individuals across different age groups.
    • To investigate potential age- and sex-related variations in CICs.
    • To explore the association between autoantibodies and CICs in older adults.

    Summary:

    • A study analyzed CICs in 413 healthy individuals using PEG-precipitation.
    • The 0-15 years age group exhibited the lowest CIC levels (3.14 ± 0.96 mg protein/ml).
    • CIC levels were similar in age groups 16-60 years (3.82–3.91 mg protein/ml), with a slight decrease in those >60 years (3.62 ± 0.75 mg protein/ml).

    Related Experiment Videos

  • No significant sex-based differences in CICs were found.
  • Autoantibodies (ANF, anti-dsDNA) were detected in 24.7% of individuals >60 years, but did not correlate with CIC levels.

    • Impact:

    • Establishes age-specific reference ranges for CICs in a healthy cohort.
    • Provides insights into normal immune complex dynamics across the lifespan.
    • Highlights the lack of correlation between common autoantibodies and CICs in healthy aging individuals.