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Lyophilized partial ossicular replacement allografts

M F Smith, J T McElveen

    The Annals of Otology, Rhinology, and Laryngology
    |September 1, 1982
    PubMed
    Summary
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    Partial ossicular replacement allografts (PORAs) effectively restored hearing in 75% of stable ears. These allografts showed no signs of extrusion or erosion, indicating a safe and viable option for ossicular reconstruction.

    Area of Science:

    • Otolaryngology
    • Surgical Innovation
    • Biomaterials in Medicine

    Background:

    • Middle ear reconstruction aims to restore hearing function.
    • Stable middle ear environments are crucial for successful reconstructive surgery.
    • Partial ossicular replacement allografts (PORAs) offer a potential solution for ossicular chain defects.

    Purpose of the Study:

    • To evaluate the efficacy and safety of partial ossicular replacement allografts (PORAs) in stable middle ear environments.
    • To assess the hearing outcomes and long-term stability of PORA usage.

    Main Methods:

    • Utilized lyophilized, ethylene oxide-sterilized PORAs for ossicular reconstruction.
    • PORAs were implanted to span the distance between the malleus and the stapes head or tympanic membrane.

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  • Patient outcomes were monitored for hearing improvement (air-bone gap closure) and graft integrity.

    • Main Results:

    • 75% (24 out of 32) of PORAs in stable ears successfully closed the air-bone gap within 10 dB.
    • In cases with unsatisfactory hearing outcomes (8 ears), the issue was apparent within one year with no further deterioration.
    • No evidence of PORA extrusion or erosion was observed during the study period.

    Conclusions:

    • Partial ossicular replacement allografts (PORAs) demonstrate significant success in achieving functional hearing restoration in stable middle ear conditions.
    • PORAs provide a durable and safe option for ossicular chain reconstruction, with no observed complications like extrusion or erosion.
    • The study supports the use of PORAs as a reliable allograft for improving hearing in patients with specific middle ear pathologies.