[Treatment experiments with glucose-induced hyperglycaemia plus Clostridium-spores on the Jensen sarcoma of rats]

Investigations Jensen's sarcoma-bearing Wistar rats demonstrate the possibility to increase significantly the oncolytic effect of an apathogenic strain of Clostridium butyricum (5 x 10(8) spores of Cl. oncolyticum M 55 i.v.) by an artificial short time hyperglycaemia (achieved maximum blood level of glucose 28.87 +/- 8.05 mmol/l). The most impressive effect was observed after a repeated application of this combination at a distance of 7 days. Both the hyperglycaemia and the application of spores have a high tumour selectivity and a relatively good compatibility. The consequence for estimations of the LDH-, ALAT- and ASAT-activity in the judgment of the therapeutical tumours damage rate is discussed.