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Corneal keloid in Lowe's syndrome
Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1982
Summary
This study examined bilateral corneal keloids in a boy with Lowe syndrome, finding haphazard collagen, fibroblasts, and vessels. The exact cause of these progressive corneal keloids remains unclear.
Area of Science:
- Ophthalmology
- Genetics
- Pathology
Background:
- Lowe syndrome is a rare genetic disorder affecting multiple organs, including the eyes.
- Corneal abnormalities, such as keloids, can occur in patients with Lowe syndrome.
- Understanding the pathogenesis of corneal keloids in this condition is crucial for potential interventions.
Observation:
- Microscopic examination of bilateral corneal keloids in a boy with Lowe syndrome was performed.
- No evidence of perforating corneal trauma or iridocorneal incarceration was observed.
- The keloids comprised disorganized collagen fibers, fibroblasts, and fenestrated blood vessels.
Findings:
- The anterior portion of the corneal keloids exhibited active progression and epithelialization.
- The etiology of keloid formation in Lowe syndrome is currently unknown.
- Potential contributing factors include amino acid imbalances, vascular leakage, endothelial dysfunction, trauma, medication, and genetic predisposition.
Implications:
- The progressive nature of corneal keloids in Lowe syndrome necessitates further investigation.
- Management strategies for these progressive corneal keloids are not established.
- Possible empirical treatments include surgical excision, pressure therapy, corticosteroids, and cromolyn sodium.